Tokyo Institute of Technology@School ofBioscience and Biotechnology

Staff List

Professeor - AKAIKE, Toshihiro
Biomedical Polymers (Blood-compatible Polymers, Cell Separation, Cell Culture, Tissue Formation)
Hybrid Artificial Organs (Liver, Pancreas, Blood vessel)
Cell Biology (Cytokines, Adhesion Molecules, Apotosis, Extracellular Matrix)
Immunology (Hepatitis) Hepatology
Drug and gene Delivery Systems
Career Histry
Name AKAIKE, Toshihiro
Doctrate University of Tokyo Ph.D. 1975 Synthetic Chemistry
Career 1990-Present

Professor of Tokyo Institute of Technology,
Graduate School of Bioscience and Biotechnology, Dept of Biomolecular Engineering

  2000-2003 Professor of Shinshu University Graduate School of Medicine ,
  1975-1980 Head of Laboratory No.3 (Research Project for High-functional membrane for molecular recognition), Kanagawa Academy of Science and Technology Foundation
  1989, 1996 Visiting Professor of University of Paris XIII

Associate Professor, Dept of Material Systems Engineering, Faculty of Technology, Tokyo University of Agriculture and Technology


Research Associate, Dept. of Surgical Science, The Heart@Institute of Japan,Tokyo Women's Medical College

Major Publication
1. Jin-Seok KIM , Beyong-ll KIM, Atsushi MARUYAMA, Toshihiro AKAIKE, Sung Wan KIM, A new non-viral DNA delivery vector: the terplex system, . Controlled Release 53 175-182 (1998)
2. Anwarul FERDOUS, Hiromitsu WATANABE, Toshihiro AKAIKE, and Atsushi MARUYAMA, Comb-Type Copolymer: Stabilization of Triplex DNA and Possible Application in Antigene Strategy, J. Pharm. Sci. 87, (11),1400-1405 (1998)
3. Watanabe, Y., Ajioka, I., Akaike, T. Gene transfection of multicellular spheroid of hepatocyte on an artificial substrate. Cytotechnology, 26, 65-78,(1998)
4. Watanabe, Y., Akaike, T. Possible involvement of caspase-like family in maintenance of cytoskeleton integrity. J. Cell .Physiol., 179, 45-51,(1998)
5. Ajioka, I., Akaike, T., Watanabe, Y., Expression of vascular endothelial growth factor (VEGF) promotes colonization, vascularization, and growth of transplatned hepatic tissues in mice. Hepatology, 29, 396-402 (1998)
6. A.Maruyama, Y. Ohnishi, H. Watanabe, H. Torigoe, A. Ferdous, T. Akaike, Polycation comb-type copolymer reduces counterion condensation effect to stabilize DNA duplex and triplex formation, Colloids and Surfaces B, 16, 273-280, (1999)
7. S. Asayama, A. Maruyama, T. Akaike, Comb-type prepolymers consisting of a polyacrylamide backbone and poly(L-lysine graft chains for multivalent ligands, Bioconjugate Chem., 10, 246-253 (1999)
8. H. Torigoe, A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Poly(l-lysine)-graft-dextran copolymer promotes pyrimidine motif triplex DNA formation at physiological pH. Thermodynamic and kinetic studies, J. Biol. Chem., 6161-6167 (1999)


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Tokyo Institute of Technology
Graduate School & School ofBioscience and Biotechnology
Akaike Laboratory